Acute Regulation of Circulating Parathyroid Hormone (PTH) Molecular Forms by Calcium: Utility of PTH Fragments/PTH(1–84) Ratios Derived from Three Generations of PTH Assays
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چکیده
منابع مشابه
Challenges of PTH Assays
Parathyroid hormone (PTH) plays a vital role in regulating of blood Calcium. In addition, it regulates the amount of phosphate and vitamin D in the blood. PTH is a polypeptide hormone that found in the blood circulation as peptides with different amino acid counts. The active form of the PTH which has biological activity, contains 84 amino acids, but under the influence of proteolytic enzymes...
متن کاملOrigin of parathyroid hormone (PTH) fragments detected by intact-PTH assays.
BACKGROUND Intact parathyroid hormone (I-PTH) assays react with non-(1-84)PTH, large carboxyl-terminal (C) fragments with a partially preserved amino-terminal (N) structure. They account for up to 50% of I-PTH in renal failure and may be implicated in PTH resistance. We wanted to know if they were secreted by the parathyroid glands and generated by peripheral metabolism of PTH(1-84). METHODS ...
متن کاملCritical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH.
Agonist-induced phosphorylation of the parathyroid hormone (PTH) receptor 1 (PTHR1) regulates receptor signaling in vitro, but the role of this phosphorylation in vivo is uncertain. We investigated this role by injecting "knock-in" mice expressing a phosphorylation-deficient (PD) PTHR1 with PTH ligands and assessing acute biologic responses. Following injection with PTH (1-34), or with a unique...
متن کاملNew lessons from old assays: parathyroid hormone (PTH), its receptors, and the potential biological relevance of PTH fragments.
Accurate and reliable measurements of the concentration of parathyroid hormone (PTH) in serum or plasma are necessary for the diagnostic assessment of various clinical disorders of bone and mineral metabolism [1,2]. In patients with chronic renal failure, serum or plasma PTH levels are commonly used to identify different subtypes of renal osteodystrophy and to monitor evolution of the disorder ...
متن کاملInfluence of glomerular filtration rate on non-(1-84) parathyroid hormone (PTH) detected by intact PTH assays.
BACKGROUND Commercial intact parathyroid hormone (I-PTH) assays detect molecular form(s) of human PTH, non-(1-84) PTH, different from the 84-amino acid native molecule. These molecular form(s) accumulate in hemodialyzed patients. We investigated the importance of non-(1-84) PTH in the interpretation of the increased I-PTH in progressive renal failure. METHODS Five groups were studied: 26 heal...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2006
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2005-1628